human HSD17B4 Over-expression AAV

Name 
AAV-h-HSD17B4
Cat No 
AAV-211578
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HSD17B4.

AAV-211578
AAV-h-HSD17B4

Ready-to-use AAV expressing Human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
17beta-estradiol dehydrogenase type IV; 17-beta-HSD 4; 17-beta-HSD IV; 17-beta-hydroxysteroid dehydrogenase 4; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; beta-hydroxyacyl dehydrogenase; beta-keto-reductase; D-3-hydroxyacyl-CoA dehydratase; D-bifunctional protein; D-bifunctional protein, peroxisomal; DBP; epididymis secretory sperm binding protein; hydroxysteroid dehydrogenase 4; MFE-2; MPF-2; multifunctional protein 2; peroxisomal multifunctional enzyme type 2; peroxisomal multifunctional protein 2; PRLTS1; SDR8C1; short chain dehydrogenase/reductase family 8C member 1
Description (eCommerce)
HSD17B4 is a bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids.It catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P51659].
Description (Vector)
HSD17B4 is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8.
Gene ID
3295
Gene Name (eCommerce)
hydroxysteroid 17-beta dehydrogenase 4
Gene Name (Vector)
hydroxysteroid 17-beta dehydrogenase 4
Gene Symbol
HSD17B4
HGNC ID
HGNC:5213
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2211
ORF Size (bp)
2211 bp
Protein Name (eCommerce)
Peroxisomal multifunctional enzyme type 2
RefSeq ID
NM_000414
RefSeq Synonyms
NM_001292028, NM_001292027, NM_001199292, NM_001199291, NM_000414, BC003098,
Research Areas
Cancer,Metabolism/Metabolic Process,Prostate Cancer
Research Areas (Faceted)
cancer,cell_biology,metabolism
Species
human
Target Sentence
HSD17B4 is a bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids.It catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P51659].
UniGene ID
Hs.406861
UniProt ID (eCommerce)
P51659

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.