human HSD11B1 Over-expression AAV

Name 
AAV-h-HSD11B1
Cat No 
AAV-211557
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HSD11B1.

AAV-211557
AAV-h-HSD11B1

Ready-to-use AAV expressing Human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
11-beta-HSD1; 11-DH; CORTRD2; HDL; HSD11; HSD11B; HSD11L; SDR26C1
Description (Vector)
HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
Gene ID
3290
Gene Name (Vector)
hydroxysteroid 11-beta dehydrogenase 1
Gene Symbol
HSD11B1
HGNC ID
HGNC:5208
ORF Size (aa)
879
ORF Size (bp)
879 bp
RefSeq ID
NM_181755
RefSeq Synonyms
NM_181755, NM_005525, NM_001206741, BC012593,
Species
human
UniGene ID
Hs.195040

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.