human HRAS Over-expression AAV

C-BAS/HAS;C-HA-RAS1;c-has/bas p21 protein;C-H-RAS;c-Ki-ras;c-K-ras;c-ras-Ki-2 activated oncogene;CTLO;GTP- and GDP-binding peptide B;GTPase HRas;GTPase KRas;HAMSV;Ha-Ras;Ha-Ras1 proto-oncoprotein;Harvey rat sarcoma viral oncogene homolog;Harvey rat sarcoma viral oncoprotein;HRAS1;H-Ras-1;H-RASIDX;Ki-Ras;KRAS;K-Ras 2;KRAS2;p19 H-RasIDX protein;p21ras;Ras family small GTP binding protein H-Ras;RASH1;RASK2;transformation gene: oncogene HAMSV;transforming protein p21;v-Ha-ras Harvey rat sarcoma viral oncogene homolog

H-Ras belongs to the Ras oncogene family, whose members bind GDP/GTP and possess intrinsic GTPase activity. They function in a variety of signal transduction pathways. H-Ras is involved primarily in regulating cell division. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. [taken from NCBI Entrez Gene (Gene ID: 3265)].

HRAS belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

3265

HRas proto-oncogene, GTPase

HRas proto-oncogene, GTPase

HRAS

HGNC:5173

9606.0

570

GTPase HRas

NM_005343

NM_176795, NM_005343, NM_001318054, NM_001130442, BC095471, BC006499,

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology

human

H-Ras belongs to the Ras oncogene family, whose members bind GDP/GTP and possess intrinsic GTPase activity. They function in a variety of signal transduction pathways. H-Ras is involved primarily in regulating cell division. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. [taken from NCBI Entrez Gene (Gene ID: 3265)].

Hs.37003

P01112