human HNF4A Over-expression AAV

Name
AAV-h-HNF4A

Cat No
AAV-211327

Availability
4-5 weeks

This is an AAV expressing Human HNF4A.

AAV-211327

AAV-h-HNF4A

Ready-to-use AAV expressing Human HNF4A (hepatocyte nuclear factor 4 alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FRTS4; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14

Description (Vector)

HNF4A is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.

Gene ID

3172

Gene Name (Vector)

hepatocyte nuclear factor 4 alpha

Gene Symbol

HNF4A

HGNC ID

HGNC:5024

ORF Size (aa)

1254

ORF Size (bp)

1254 bp

RefSeq ID

NM_000457

RefSeq Synonyms

NM_178850, NM_178849, NM_175914, NM_001287184, NM_001287183, NM_001287182, NM_001258355, NM_001030004, NM_001030003, NM_000457, BC137540, BC137539,

Species

human

UniGene ID

Hs.116462

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.