human HEXIM1 Over-expression AAV

Name 
AAV-h-HEXIM1
Cat No 
AAV-210983
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HEXIM1.

AAV-210983
AAV-h-HEXIM1

Ready-to-use AAV expressing Human HEXIM1 (hexamethylene bisacetamide inducible 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
cardiac lineage protein 1; CLP1; EDG1; estrogen down-regulated gene 1 protein; hexamethylene bis-acetamide inducible 1; hexamethylene bisacetamide-inducible protein; hexamethylene bis-acetamide-inducible protein 1; hexamethylene-bis-acetamide-inducible transcript 1; hexamthylene bis-acetamide inducible 1; HIS1; HMBA-inducible; MAQ1; menage a quatre 1; menage a quatre protein 1; protein HEXIM1
Description (eCommerce)
Hexamethylene bis-acetamide-inducible protein 1 (HEXIM1) is a transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA, HEXIM1sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM1 may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O94992].
Description (Vector)
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.
Gene ID
10614
Gene Name (eCommerce)
hexamethylene bisacetamide inducible 1
Gene Name (Vector)
hexamethylene bisacetamide inducible 1
Gene Symbol
HEXIM1
HGNC ID
HGNC:24953
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1080
ORF Size (bp)
1080 bp
Protein Name (eCommerce)
Protein HEXIM1
RefSeq ID
NM_006460
RefSeq Synonyms
NM_006460, BC006460,
Research Areas
Cardiac Development,Cardiology,Cardiovascular,RNA Binding,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,transcription_translation
Species
human
Target Sentence
Hexamethylene bis-acetamide-inducible protein 1 (HEXIM1) is a transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA, HEXIM1sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM1 may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O94992].
UniGene ID
Hs.716487
UniProt ID (eCommerce)
O94992

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.