human HCST Over-expression AAV

Name 
AAV-h-HCST
Cat No 
AAV-210880
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human HCST.

AAV-210880
AAV-h-HCST

Ready-to-use AAV expressing Human HCST (hematopoietic cell signal transducer). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DAP10; KAP10; PIK3AP
Description (Vector)
HCST encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.
Gene ID
10870
Gene Name (Vector)
hematopoietic cell signal transducer
Gene Symbol
HCST
HGNC ID
HGNC:16977
ORF Size (aa)
282
RefSeq ID
NM_014266
RefSeq Synonyms
NM_014266, NM_001007469, BC065224, BC046348, BC035931,
Species
human
UniGene ID
Hs.117339

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.