human GUCY2D Over-expression AAV

Name 
AAV-h-GUCY2D
Cat No 
AAV-210692
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GUCY2D.

AAV-210692
AAV-h-GUCY2D

Ready-to-use AAV expressing Human GUCY2D (guanylate cyclase 2D, retinal). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CORD5; CORD6; CYGD; GUC1A4; GUC2D; LCA; LCA1; RCD2; retGC; RETGC-1; ROS-GC1; ROSGC
Description (Vector)
GUCY2D encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases.
Gene ID
3000
Gene Name (Vector)
guanylate cyclase 2D, retinal
Gene Symbol
GUCY2D
HGNC ID
HGNC:4689
ORF Size (aa)
3309
ORF Size (bp)
3309 bp
RefSeq ID
NM_000180
RefSeq Synonyms
NM_000180, BC148421,
Species
human
UniGene ID
Hs.592109

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.