human GPT Over-expression AAV

Name
AAV-h-GPT

Cat No
AAV-210451

Availability
4-5 weeks

This is an AAV expressing Human GPT.

AAV-210451

AAV-h-GPT

Ready-to-use AAV expressing Human GPT (glutamic–pyruvic transaminase). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AAT1; ALT1; GPT1

Description (Vector)

GPT encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.

Gene ID

2875

Gene Name (Vector)

glutamic--pyruvic transaminase

Gene Symbol

GPT

HGNC ID

HGNC:4552

ORF Size (aa)

1491

ORF Size (bp)

1491 bp

RefSeq ID

NM_005309

RefSeq Synonyms

NM_005309, BC018207,

Species

human

UniGene ID

Hs.103502

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.