human GPS2 Over-expression AAV

Name 
AAV-h-GPS2
Cat No 
AAV-210440
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GPS2.

AAV-210440
AAV-h-GPS2

Ready-to-use AAV expressing Human GPS2 (G protein pathway suppressor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AMF-1
Description (Vector)
GPS2 encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.
Gene ID
2874
Gene Name (Vector)
G protein pathway suppressor 2
Gene Symbol
GPS2
HGNC ID
HGNC:4550
ORF Size (aa)
984
ORF Size (bp)
984 bp
RefSeq ID
NM_004489
RefSeq Synonyms
NM_004489, BC107738, BC103903, BC103901, BC013652,
Species
human
UniGene ID
Hs.438219

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.