human GP6 Over-expression AAV

Name
AAV-h-GP6

Cat No
AAV-210191

Availability
4-5 weeks

This is an AAV expressing Human GP6.

AAV-210191

AAV-h-GP6

Ready-to-use AAV expressing Human GP6 (glycoprotein VI platelet). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BDPLT11; GPIV; GPVI

Description (Vector)

GP6 encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

51206

Gene Name (Vector)

glycoprotein VI platelet

Gene Symbol

GP6

HGNC ID

HGNC:14388

ORF Size (aa)

1020

ORF Size (bp)

1020 bp

RefSeq ID

NM_016363

RefSeq Synonyms

NM_016363, NM_001256017, NM_001083899, BC111963, BC104832,

Species

human

UniGene ID

Hs.661752

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.