human GNS Over-expression AAV

Name
AAV-h-GNS

Cat No
AAV-210146

Availability
4-5 weeks

This is an AAV expressing Human GNS.

AAV-210146

AAV-h-GNS

Ready-to-use AAV expressing Human GNS (glucosamine (N-acetyl)-6-sulfatase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

G6S

Description (Vector)

The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.

Gene ID

2799

Gene Name (Vector)

glucosamine (N-acetyl)-6-sulfatase

Gene Symbol

GNS

HGNC ID

HGNC:4422

ORF Size (aa)

1659

ORF Size (bp)

1659 bp

RefSeq ID

NM_002076

RefSeq Synonyms

NM_002076, BC012482,

Species

human

UniGene ID

Hs.334534

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.