human GAN Over-expression AAV

Name 
AAV-h-GAN
Cat No 
AAV-209628
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GAN.

AAV-209628
AAV-h-GAN

Ready-to-use AAV expressing Human GAN (gigaxonin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
epididymis secretory sperm binding protein; GAN1; gigaxonin; kelch-like family member 16; kelch-like protein 16; KLHL16
Description (eCommerce)
Gigaxonin is a probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It is also a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins such as TBCB, MAP1B, and MAP1S and is critical for neuronal maintenance and survival [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9H2C0].
Description (Vector)
GAN encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN).
Gene ID
8139
Gene Name (eCommerce)
gigaxonin
Gene Name (Vector)
gigaxonin
Gene Symbol
GAN
HGNC ID
HGNC:4137
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1794
ORF Size (bp)
1794 bp
Protein Name (eCommerce)
Gigaxonin
RefSeq ID
NM_022041
RefSeq Synonyms
NM_022041, BC044840,
Research Areas
Antigen Processing and Presentation,Apoptosis,Cytoskeleton,Immunology,Neurobiology,Neurodegeneration,Ubiquitination
Research Areas (Faceted)
cell_biology,immunology,neurobiology
Species
human
Target Sentence
Gigaxonin is a probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It is also a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins such as TBCB, MAP1B, and MAP1S and is critical for neuronal maintenance and survival [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9H2C0].
UniGene ID
Hs.112569
UniProt ID (eCommerce)
Q9H2C0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.