human GAN shRNA silencing AAV

Name
AAV-h-GAN-shRNA

Cat No
shAAV-209628

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human GAN.

shAAV-209628

AAV-h-GAN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human GAN (gigaxonin). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

epididymis secretory sperm binding protein; GAN1; gigaxonin; kelch-like family member 16; kelch-like protein 16; KLHL16

Description (eCommerce)

Gigaxonin is a probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It is also a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins such as TBCB, MAP1B, and MAP1S and is critical for neuronal maintenance and survival [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9H2C0].

Description (Vector)

GAN encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN).

Gene ID

8139

Gene Name (eCommerce)

gigaxonin

Gene Name (Vector)

gigaxonin

Gene Symbol

GAN

HGNC ID

HGNC:4137

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1794

ORF Size (bp)

1794 bp

Protein Name (eCommerce)

Gigaxonin

RefSeq ID

NM_022041

RefSeq Synonyms

NM_022041, BC044840,

Research Areas

Antigen Processing and Presentation,Apoptosis,Cytoskeleton,Immunology,Neurobiology,Neurodegeneration,Ubiquitination

Research Areas (Faceted)

cell_biology,immunology,neurobiology

Species

human

Target Sentence

Gigaxonin is a probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It is also a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins such as TBCB, MAP1B, and MAP1S and is critical for neuronal maintenance and survival [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9H2C0].

UniGene ID

Hs.112569

UniProt ID (eCommerce)

Q9H2C0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.