human GADD45B Over-expression AAV

Name 
AAV-h-GADD45B
Cat No 
AAV-209542
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human GADD45B.

AAV-209542
AAV-h-GADD45B

Ready-to-use AAV expressing Human GADD45B (growth arrest and DNA damage inducible beta). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
GADD45BETA; MYD118
Description (Vector)
GADD45B is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.
Gene ID
4616
Gene Name (Vector)
growth arrest and DNA damage inducible beta
Gene Symbol
GADD45B
HGNC ID
HGNC:4096
ORF Size (aa)
483
RefSeq ID
NM_015675
RefSeq Synonyms
NM_015675, BC117469, BC113466,
Species
human
UniGene ID
Hs.110571

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.