human FTO Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-209388
Availability:
3-5 weeks
Name:
AAV-h-FTO
This is an AAV expressing Human FTO.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- FTO
- Gene Name
- FTO, alpha-ketoglutarate dependent dioxygenase
- Gene ID
- 79068
- Gene Synonyms
- ALKBH9; BMIQ14; GDFD
- ORF Size
- 1518 bp
- RefSeq#
- BC153032
- Gene Description
- FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.
- UniGene ID
- Hs.528833
- HGNC ID
- HGNC:24678
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