human FGF23 Over-expression AAV

Name
AAV-h-FGF23

Cat No
AAV-208967

Availability
4-5 weeks

This is an AAV expressing Human FGF23.

AAV-208967

AAV-h-FGF23

Ready-to-use AAV expressing Human FGF23 (fibroblast growth factor 23). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADHR; FGFN; HPDR2; HYPF; PHPTC

Description (Vector)

FGF23 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.

Gene ID

8074

Gene Name (Vector)

fibroblast growth factor 23

Gene Symbol

FGF23

HGNC ID

HGNC:3680

ORF Size (aa)

756

ORF Size (bp)

756 bp

RefSeq ID

NM_020638

RefSeq Synonyms

NM_020638, BC098252, BC098147, BC096713, BC069333,

Species

human

UniGene ID

Hs.287370

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.