human ETV6 Over-expression AAV

Name 
AAV-h-ETV6
Cat No 
AAV-208150
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ETV6.

AAV-208150
AAV-h-ETV6

Ready-to-use AAV expressing Human ETV6 (ETS variant 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ETS translocation variant 6; ets variant gene 6 (TEL oncogene); ETS-related protein Tel1; TEL; TEL/ABL; TEL1 oncogene; THC5; transcription factor ETV6
Description (eCommerce)
ETS translocation variant 6 (ETV6) functions as a transcriptional repressor. Gene knockout studies in mice suggest that ETV6 is required for hematopoiesis and maintenance of the developing vascular network. The ETV6 gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma [taken from NCBI Entrez Gene (Gene ID: 2120)].
Description (Vector)
ETV6 encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. ETV6 is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
Gene ID
2120
Gene Name (eCommerce)
ETS variant 6
Gene Name (Vector)
ETS variant 6
Gene Symbol
ETV6
HGNC ID
HGNC:3495
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1359
ORF Size (bp)
1359 bp
Protein Name (eCommerce)
Transcription factor ETV6
RefSeq ID
NM_001987
RefSeq Synonyms
NM_001987, BC043399,
Research Areas
Cancer,FGF Signaling,Signal Transduction,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,cell_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
ETS translocation variant 6 (ETV6) functions as a transcriptional repressor. Gene knockout studies in mice suggest that ETV6 is required for hematopoiesis and maintenance of the developing vascular network. The ETV6 gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma [taken from NCBI Entrez Gene (Gene ID: 2120)].
UniGene ID
Hs.504765
UniProt ID (eCommerce)
P41212

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.