human ETV1 Over-expression AAV

Name
AAV-h-ETV1

Cat No
AAV-208142

Availability
4-5 weeks

Categories
AAV, Over-Expression

This is an AAV expressing Human ETV1.

AAV-208142

AAV-h-ETV1

Ready-to-use AAV expressing Human ETV1 (ETS variant 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ER81

Description (Vector)

ETV1 encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA(AT)-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. ETV1 is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

2115

Gene Name (Vector)

ETS variant 1

Gene Symbol

ETV1

HGNC ID

HGNC:3490

ORF Size (aa)

1434

ORF Size (bp)

1434 bp

RefSeq ID

NM_004956

RefSeq Synonyms

NM_004956, NM_001163152, NM_001163151, NM_001163150, NM_001163149, NM_001163148, NM_001163147, BC106763, BC106762, BC098403,

Species

human

UniGene ID

Hs.22634

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.