human ESCO2 Over-expression AAV

Name 
AAV-h-ESCO2
Cat No 
AAV-208103
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ESCO2.

AAV-208103
AAV-h-ESCO2

Ready-to-use AAV expressing Human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
2410004I17Rik; ECO1 homolog 2; EFO2; Establishment of cohesion 1 homolog 2; N-acetyltransferase ESCO2; RBS
Description (eCommerce)
ESCO2 (establishment of cohesion 1 homolog2) is an acetyltransferase that is essential to sister chromatid cohesion during S phase. Recent studies reveal that ESCO2 associates with components of the CoREST transcriptional repression complex. ESCO2 has also been shown to possess histone H3 K9 methylation activity. These findings suggest a role for ESCO2 in transcriptional regulation via the modulation of chromatin structure.
Description (Vector)
ESCO2 encodes a protein that may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis. Mutations in this gene have been associated with Roberts syndrome.
Gene ID
157570
Gene Name (eCommerce)
establishment of sister chromatid cohesion N-acetyltransferase 2
Gene Name (Vector)
establishment of sister chromatid cohesion N-acetyltransferase 2
Gene Symbol
ESCO2
HGNC ID
HGNC:27230
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1806
ORF Size (bp)
1806 bp
Protein Name (eCommerce)
N-acetyltransferase ESCO2
RefSeq ID
NM_001017420
RefSeq Synonyms
NM_001017420, BC146562, BC141418,
Research Areas
Acyltransferase,Cell Cycle,Cell Division,DNA Replication,Translational Control,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
ESCO2 (establishment of cohesion 1 homolog2) is an acetyltransferase that is essential to sister chromatid cohesion during S phase. Recent studies reveal that ESCO2 associates with components of the CoREST transcriptional repression complex. ESCO2 has also been shown to possess histone H3 K9 methylation activity. These findings suggest a role for ESCO2 in transcriptional regulation via the modulation of chromatin structure.
UniGene ID
Hs.99480
UniProt ID (eCommerce)
Q56NI9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.