human ENPP2 Over-expression AAV

Name
AAV-h-ENPP2

Cat No
AAV-207930

Availability
4-5 weeks

This is an AAV expressing Human ENPP2.

AAV-207930

AAV-h-ENPP2

Ready-to-use AAV expressing Human ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ATX; ATX-X; AUTOTAXIN; LysoPLD; NPP2; PD-IALPHA; PDNP2

Description (Vector)

ENPP2 functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

5168

Gene Name (Vector)

ectonucleotide pyrophosphatase/phosphodiesterase 2

Gene Symbol

ENPP2

HGNC ID

HGNC:3357

ORF Size (aa)

2592

ORF Size (bp)

2592 bp

RefSeq ID

NM_006209

RefSeq Synonyms

NM_006209, NM_001330600, NM_001130863, NM_001040092, BC034961,

Species

human

UniGene ID

Hs.190977

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.