human DENR Over-expression AAV

Name 
AAV-h-DENR
Cat No 
AAV-206877
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human DENR.

AAV-206877
AAV-h-DENR

Ready-to-use AAV expressing Human DENR (density regulated re-initiation and release factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
density-regulated protein; DRP; DRP1; Protein DRP1; SMAP-3; smooth muscle cell associated protein-3; Smooth muscle cell-associated protein 3
Description (eCommerce)
Density regulated protein (DRP) may be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. DRP plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O43583].
Description (Vector)
DENR encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. DENR was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants.
Gene ID
8562
Gene Name (eCommerce)
density regulated re-initiation and release factor
Gene Name (Vector)
density regulated re-initiation and release factor
Gene Symbol
DENR
HGNC ID
HGNC:2769
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
597
ORF Size (bp)
597 bp
Protein Name (eCommerce)
Density-regulated protein
RefSeq ID
NM_003677
RefSeq Synonyms
NM_003677, BC007860,
Research Areas
Translational Control
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Density regulated protein (DRP) may be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. DRP plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O43583].
UniGene ID
Hs.22393
UniProt ID (eCommerce)
O43583

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.