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human DENR shRNA silencing Adenovirus

Name 
Ad-h-DENR-shRNA
Cat No 
shADV-206877
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DENR.

shADV-206877
Ad-h-DENR-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DENR (density regulated re-initiation and release factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
density-regulated protein; DRP; DRP1; Protein DRP1; SMAP-3; smooth muscle cell associated protein-3; Smooth muscle cell-associated protein 3
Description (eCommerce)
Density regulated protein (DRP) may be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. DRP plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O43583].
Description (Vector)
DENR encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. DENR was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants.
Gene ID
8562
Gene Name (eCommerce)
density regulated re-initiation and release factor
Gene Name (Vector)
density regulated re-initiation and release factor
Gene Symbol
DENR
HGNC ID
HGNC:2769
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
597
ORF Size (bp)
597 bp
Protein Name (eCommerce)
Density-regulated protein
RefSeq ID
NM_003677
RefSeq Synonyms
NM_003677, BC007860,
Research Areas
Translational Control
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
Density regulated protein (DRP) may be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. DRP plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O43583].
UniGene ID
Hs.22393
UniProt ID (eCommerce)
O43583

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.