human CYP24A1 Over-expression AAV

Name
AAV-h-CYP24A1

Cat No
AAV-206462

Availability
4-5 weeks

This is an AAV expressing Human CYP24A1.

AAV-206462

AAV-h-CYP24A1

Ready-to-use AAV expressing Human CYP24A1 (cytochrome P450 family 24 subfamily A member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CP24; CYP24; HCAI; HCINF1; P450-CC24

Description (Vector)

CYP24A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

1591

Gene Name (Vector)

cytochrome P450 family 24 subfamily A member 1

Gene Symbol

CYP24A1

HGNC ID

HGNC:2602

ORF Size (aa)

1347

ORF Size (bp)

1347 bp

RefSeq ID

NM_000782

RefSeq Synonyms

NM_001128915, NM_000782, BC109084, BC109083,

Species

human

UniGene ID

Hs.89663

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.