human CSTB Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-206189
Availability:
3-5 weeks
Name:
AAV-h-CSTB
This is an AAV expressing Human CSTB.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- CSTB
- Gene Name
- cystatin B
- Gene ID
- 1476
- Gene Synonyms
- CPI-B; CST6; EPM1; EPM1A; PME; STFB; ULD
- ORF Size
- 297 bp
- RefSeq#
- BC003370
- Gene Description
- The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
- UniGene ID
- Hs.695
- HGNC ID
- HGNC:2482
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