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human CRTC3 Over-expression AAV

Name 
AAV-h-CRTC3
Cat No 
AAV-206040
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CRTC3.

AAV-206040
AAV-h-CRTC3

Ready-to-use AAV expressing Human CRTC3 (CREB regulated transcription coactivator 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CREB-regulated transcription coactivator 3; TORC3; TORC-3; Transducer of CREB protein 3; transducer of regulated cAMP response element-binding protein (CREB) 3; Transducer of regulated cAMP response element-binding protein 3; transducer of regulated CREB protein 3
Description (eCommerce)
TORC3 (transducer of regulated cAMP response element-binding protein 3) is a transcriptional coactivator for CREB1 which activates transcription through cAMP response element (CRE) sites. TORC3 acts as a coactivator in the SIK/TORC signaling pathway. TORC3 has also been shown to be a coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Description (Vector)
CRTC3 is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Gene ID
64784
Gene Name (eCommerce)
CREB regulated transcription coactivator 3
Gene Name (Vector)
CREB regulated transcription coactivator 3
Gene Symbol
CRTC3
HGNC ID
HGNC:26148
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
963
ORF Size (bp)
963 bp
Protein Name (eCommerce)
CREB-regulated transcription coactivator 3
RefSeq ID
NM_022769
RefSeq Synonyms
NM_022769, NM_001042574, BC074731,
Research Areas
Host-Virus Interactions,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,infectious_disease,transcription_translation
Species
human
Target Sentence
TORC3 (transducer of regulated cAMP response element-binding protein 3) is a transcriptional coactivator for CREB1 which activates transcription through cAMP response element (CRE) sites. TORC3 acts as a coactivator in the SIK/TORC signaling pathway. TORC3 has also been shown to be a coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
UniGene ID
Hs.567572
UniProt ID (eCommerce)
Q6UUV7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.