human CISH Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-205295
Availability:
3-5 weeks
Name:
AAV-h-CISH
This is an AAV expressing Human CISH.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- CISH
- Gene Name
- cytokine inducible SH2 containing protein
- Gene ID
- 1154
- Gene Synonyms
- BACTS2; CIS; CIS-1; G18; SOCS
- ORF Size
- 777 bp
- RefSeq#
- BC064354
- Gene Description
- CISH contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
- UniGene ID
- Hs.655334
- HGNC ID
- HGNC:1984
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