human CIR Over-expression AAV

Name
AAV-h-CIR

Cat No
AAV-205286

Availability
4-5 weeks

This is an AAV expressing Human CIR1.

AAV-205286

AAV-h-CIR

Ready-to-use AAV expressing Human CIR1 (corepressor interacting with RBPJ, 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CBF1-interacting corepressor; CIR; corepressor interacting with RBPJ 1; recepin

Description (eCommerce)

Corepressor interacting with RBPJ (CIR1) may modulate splice site selection during alternative splicing of pre-mRNAs (by similarity). CIR1 regulates transcription and acts as a corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC) and is required for RBPJ-mediated repression of transcription [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86X95].

Gene ID

9541

Gene Name (eCommerce)

corepressor interacting with RBPJ, 1

Gene Name (Vector)

corepressor interacting with RBPJ, 1

Gene Symbol

CIR1

HGNC ID

HGNC:24217

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1353

ORF Size (bp)

1353 bp

Protein Name (eCommerce)

Corepressor interacting with RBPJ 1

RefSeq ID

NM_004882

RefSeq Synonyms

NM_004882, BC046098, BC015040,

Research Areas

Cytoskeleton,mRNA Processing,mRNA Splicing,Notch Signaling,RNA Processing,Signal Transduction,Transcription Factor/Regulator

Research Areas (Faceted)

signal_transduction,cell_biology,genetics,transcription_translation,signal_transduction,developmental_biology,genetics,transcription_translation

Species

human

Target Sentence

Corepressor interacting with RBPJ (CIR1) may modulate splice site selection during alternative splicing of pre-mRNAs (by similarity). CIR1 regulates transcription and acts as a corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC) and is required for RBPJ-mediated repression of transcription [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86X95].

UniGene ID

Hs.632531

UniProt ID (eCommerce)

Q86X95

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.