human CIR shRNA silencing AAV

Name
AAV-h-CIR-shRNA

Cat No
shAAV-205286

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CIR1.

shAAV-205286

AAV-h-CIR-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CIR1 (corepressor interacting with RBPJ, 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CBF1-interacting corepressor; CIR; corepressor interacting with RBPJ 1; recepin

Description (eCommerce)

Corepressor interacting with RBPJ (CIR1) may modulate splice site selection during alternative splicing of pre-mRNAs (by similarity). CIR1 regulates transcription and acts as a corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC) and is required for RBPJ-mediated repression of transcription [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86X95].

Gene ID

9541

Gene Name (eCommerce)

corepressor interacting with RBPJ, 1

Gene Name (Vector)

corepressor interacting with RBPJ, 1

Gene Symbol

CIR1

HGNC ID

HGNC:24217

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1353

ORF Size (bp)

1353 bp

Protein Name (eCommerce)

Corepressor interacting with RBPJ 1

RefSeq ID

NM_004882

RefSeq Synonyms

NM_004882, BC046098, BC015040,

Research Areas

Cytoskeleton,mRNA Processing,mRNA Splicing,Notch Signaling,RNA Processing,Signal Transduction,Transcription Factor/Regulator

Research Areas (Faceted)

signal_transduction,cell_biology,genetics,transcription_translation,signal_transduction,developmental_biology,genetics,transcription_translation

Species

human

Target Sentence

Corepressor interacting with RBPJ (CIR1) may modulate splice site selection during alternative splicing of pre-mRNAs (by similarity). CIR1 regulates transcription and acts as a corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC) and is required for RBPJ-mediated repression of transcription [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86X95].

UniGene ID

Hs.632531

UniProt ID (eCommerce)

Q86X95

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.