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human CFL2 Over-expression AAV

Name 
AAV-h-CFL2
Cat No 
AAV-205053
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CFL2.

AAV-205053
AAV-h-CFL2

Ready-to-use AAV expressing Human CFL2 (cofilin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
NEM7
Description (Vector)
CFL2 encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
Gene ID
1073
Gene Name (Vector)
cofilin 2
Gene Symbol
CFL2
HGNC ID
HGNC:1875
ORF Size (aa)
501
ORF Size (bp)
501 bp
RefSeq ID
NM_021914
RefSeq Synonyms
NM_138638, NM_021914, NM_001243645, BC022876, BC022364, BC011444,
Species
human
UniGene ID
Hs.180141

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.