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human CDKN2B Over-expression AAV

Name 
AAV-h-CDKN2B
Cat No 
AAV-204883
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CDKN2B.

AAV-204883
AAV-h-CDKN2B

Ready-to-use AAV expressing Human CDKN2B (cyclin dependent kinase inhibitor 2B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CDK4I; INK4B; MTS2; P15; p15INK4b; TP15
Description (Vector)
CDKN2B lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Gene ID
1030
Gene Name (Vector)
cyclin dependent kinase inhibitor 2B
Gene Symbol
CDKN2B
HGNC ID
HGNC:1788
ORF Size (aa)
417
ORF Size (bp)
417 bp
RefSeq ID
NM_078487
RefSeq Synonyms
NM_078487, NM_004936, BC014469,
Species
human
UniGene ID
Hs.72901

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.