human CCAR1 Over-expression AAV

Name
AAV-h-CCAR1

Cat No
AAV-204211

Availability
4-5 weeks

This is an AAV expressing Human CCAR1.

AAV-204211

AAV-h-CCAR1

Ready-to-use AAV expressing Human CCAR1 (cell division cycle and apoptosis regulator 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CARP-1; cell cycle and apoptosis regulatory protein 1; cell division cycle and apoptosis regulator protein 1; death inducer with SAP domain

Description (eCommerce)

CCAR1 was identified as a perinuclear phosphoprotein that regulates apoptosis signals in response to chemotherapeutic agents. Induction of apoptosis by CCAR1 involves the epidermal growth factor receptor (EGFR), mitogen-activated protein kinase pathway and caspase-9 activation. CARP-1 has also been demonstrated as a suppressor of human breast cancer growth.

Gene ID

55749

Gene Name (eCommerce)

cell division cycle and apoptosis regulator 1

Gene Name (Vector)

cell division cycle and apoptosis regulator 1

Gene Symbol

CCAR1

HGNC ID

HGNC:24236

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3453

ORF Size (bp)

3453 bp

Protein Name (eCommerce)

Cell division cycle and apoptosis regulator protein 1

RefSeq ID

NM_018237

RefSeq Synonyms

NM_018237, NM_001282960, NM_001282959, BC132725, BC130626,

Research Areas

Apoptosis,Cell Cycle,Gene Expression,mRNA Processing,mRNA Splicing,RNA Processing,Spliceosome,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,transcription_translation,cell_biology,genetics

Species

human

Target Sentence

CCAR1 was identified as a perinuclear phosphoprotein that regulates apoptosis signals in response to chemotherapeutic agents. Induction of apoptosis by CCAR1 involves the epidermal growth factor receptor (EGFR), mitogen-activated protein kinase pathway and caspase-9 activation. CARP-1 has also been demonstrated as a suppressor of human breast cancer growth.

UniGene ID

Hs.49853

UniProt ID (eCommerce)

Q8IX12

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.