human CBFA2T3 Over-expression AAV

Name 
AAV-h-CBFA2T3
Cat No 
AAV-204158
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CBFA2T3.

AAV-204158
AAV-h-CBFA2T3

Ready-to-use AAV expressing Human CBFA2T3 (CBFA2/RUNX1 translocation partner 3). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
core-binding factor, runt domain, alpha subunit 2; translocated to, 3; ETO2; hMTG16; MTG16; MTG8-related gene 2; MTG8-related protein 2; MTGR2; myeloid translocation gene 8 and 16b; myeloid translocation gene on chromosome 16 protein; protein CBFA2T3; RUNX1T3; zinc finger MYND domain-containing protein 4; ZMYND4
Description (eCommerce)
CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a member of the myeloid translocation gene family which interacts with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of the CBFA2T3 gene. This gene is also a putative breast tumor suppressor. [taken from NCBI Entrez Gene (Gene ID: 863)].
Description (Vector)
CBFA2T3 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. CBFA2T3 is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.
Gene ID
863
Gene Name (eCommerce)
CBFA2/RUNX1 translocation partner 3
Gene Name (Vector)
CBFA2/RUNX1 translocation partner 3
Gene Symbol
CBFA2T3
HGNC ID
HGNC:1537
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1962
ORF Size (bp)
1962 bp
Protein Name (eCommerce)
Protein CBFA2T3
RefSeq ID
NM_005187
RefSeq Synonyms
NM_175931, NM_005187, BC062624, BC047019,
Research Areas
Golgi Apparatus,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a member of the myeloid translocation gene family which interacts with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of the CBFA2T3 gene. This gene is also a putative breast tumor suppressor. [taken from NCBI Entrez Gene (Gene ID: 863)].
UniGene ID
Hs.513811
UniProt ID (eCommerce)
O75081

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.