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human CBFA2T2 Over-expression AAV

Name 
AAV-h-CBFA2T2
Cat No 
AAV-204157
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CBFA2T2.

AAV-204157
AAV-h-CBFA2T2

Ready-to-use AAV expressing Human CBFA2T2 (CBFA2/RUNX1 translocation partner 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
core-binding factor, runt domain, alpha subunit 2; translocated to, 2; EHT; ETO homolog on chromosome 20; ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; MTGR1; myeloid translocation gene-related protein 1; myeloid translocation-related protein 1; p85; protein CBFA2T2; ZMYND3
Description (eCommerce)
CBFA2T2 may function in a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). CBFA2T2 may thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. CBF2T2 may be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O43439].
Description (Vector)
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Gene ID
9139
Gene Name (eCommerce)
CBFA2/RUNX1 translocation partner 2
Gene Name (Vector)
CBFA2/RUNX1 translocation partner 2
Gene Symbol
CBFA2T2
HGNC ID
HGNC:1536
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1845
ORF Size (bp)
1845 bp
Protein Name (eCommerce)
Protein CBFA2T2
RefSeq ID
NM_005093
RefSeq Synonyms
NM_005093, NM_001039709, NM_001032999, BC040344, BC015066,
Research Areas
Neurobiology,Neurodevelopment,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,transcription_translation
Species
human
Target Sentence
CBFA2T2 may function in a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). CBFA2T2 may thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. CBF2T2 may be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O43439].
UniGene ID
Hs.153934
UniProt ID (eCommerce)
O43439

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.