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human C7ORF23 Over-expression AAV

Name 
AAV-h-C7ORF23
Cat No 
AAV-203648
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human DMTF1.

AAV-203648
AAV-h-C7ORF23

Ready-to-use AAV expressing Human DMTF1 (cyclin D binding myb like transcription factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DMP1; DMTF; hDMP1; MRUL
Description (Vector)
DMTF1 encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. DMTF1 is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
9988
Gene Name (Vector)
cyclin D binding myb like transcription factor 1
Gene Symbol
DMTF1
HGNC ID
HGNC:14603
ORF Size (aa)
2283
ORF Size (bp)
2283 bp
RefSeq ID
NM_021145
RefSeq Synonyms
NM_021145, NM_001142327, NM_001142326, BC070064,
Species
human
UniGene ID
Hs.196129

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.