human BRD8 Over-expression AAV
This is an AAV expressing Human BRD8.
AAV-202260
AAV-h-BRD8
Ready-to-use AAV expressing Human BRD8 (bromodomain containing 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
bromodomain-containing protein 8; p120; Skeletal muscle abundant protein; skeletal muscle abundant protein 2; SMAP; SMAP2; thyroid hormone receptor coactivating protein of 120 kDa; trCP120
Description (eCommerce)
BRD8 (bromodomain-containing 8) has been identified as a thyroid hormone receptor coactivator as well as a GTPase activating protein (GAP) for Arf6 that regulates clathrin-dependent vesicle trafficking. BRD8 has also been identified as a gene upregulated during formation of the neointima layer of blood vessels and named smooth muscle activating protein 2 (SMAP2).
Description (Vector)
BRD8 interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.
Gene ID
10902
Gene Name (eCommerce)
bromodomain containing 8
Gene Name (Vector)
bromodomain containing 8
Gene Symbol
BRD8
HGNC ID
HGNC:19874
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2763
ORF Size (bp)
2763 bp
Protein Name (eCommerce)
Bromodomain-containing protein 8
RefSeq ID
NM_006696
RefSeq Synonyms
NM_139199, NM_006696, NM_001300966, NM_001300962, NM_001300961, NM_001164326, BC008076, BC008039,
Research Areas
Chromatin Remodeling,Histone Modification,Mitochondrion,Nuclear Receptor Coactivators,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
BRD8 (bromodomain-containing 8) has been identified as a thyroid hormone receptor coactivator as well as a GTPase activating protein (GAP) for Arf6 that regulates clathrin-dependent vesicle trafficking. BRD8 has also been identified as a gene upregulated during formation of the neointima layer of blood vessels and named smooth muscle activating protein 2 (SMAP2).
UniGene ID
Hs.519337
UniProt ID (eCommerce)
Q9H0E9
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.