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human BEST1 Over-expression AAV

Name 
AAV-h-BEST1
Cat No 
AAV-202098
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BEST1.

AAV-202098
AAV-h-BEST1

Ready-to-use AAV expressing Human BEST1 (bestrophin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ARB; BEST; BMD; RP50; TU15B; VMD2
Description (Vector)
BEST1 encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
Gene ID
7439
Gene Name (Vector)
bestrophin 1
Gene Symbol
BEST1
HGNC ID
HGNC:12703
ORF Size (aa)
1815
ORF Size (bp)
1815 bp
RefSeq ID
NM_004183
RefSeq Synonyms
NM_004183, NM_001300787, NM_001300786, NM_001139443, BC041664, BC015220,
Species
human
UniGene ID
Hs.712676

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.