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human BCL2L11 Over-expression AAV

Name 
AAV-h-BCL2L11
Cat No 
AAV-202043
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BCL2L11.

AAV-202043
AAV-h-BCL2L11

Ready-to-use AAV expressing Human BCL2L11 (BCL2 like 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BAM; BIM; BOD
Description (Vector)
BCL2L11 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
Gene ID
10018
Gene Name (Vector)
BCL2 like 11
Gene Symbol
BCL2L11
HGNC ID
HGNC:994
ORF Size (aa)
597
ORF Size (bp)
597 bp
RefSeq ID
NM_138621
RefSeq Synonyms
NM_207003, NM_207002, NM_138627, NM_138626, NM_138625, NM_138624, NM_138623, NM_138622, NM_138621, NM_006538, NM_001204113, NM_001204112, NM_001204111, NM_001204110, NM_001204109, NM_001204108, NM_001204107, NM_001204106, BC033694,
Species
human
UniGene ID
Hs.469658

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.