human BCL2A1 Over-expression AAV

Name
AAV-h-BCL2A1

Cat No
AAV-202037

Availability
4-5 weeks

This is an AAV expressing Human BCL2A1.

AAV-202037

AAV-h-BCL2A1

Ready-to-use AAV expressing Human BCL2A1 (BCL2 related protein A1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACC-1; ACC-2; ACC1; ACC2; BCL2L5; BFL1; GRS; HBPA1

Description (Vector)

BCL2A1 encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. BCL2A1 is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

597

Gene Name (Vector)

BCL2 related protein A1

Gene Symbol

BCL2A1

HGNC ID

HGNC:991

ORF Size (aa)

528

ORF Size (bp)

528 bp

RefSeq ID

NM_004049

RefSeq Synonyms

NM_004049, NM_001114735, BC016281,

Species

human

UniGene ID

Hs.227817

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.