human BCL10 Over-expression AAV

Name
AAV-h-BCL10

Cat No
AAV-202033

Availability
4-5 weeks

This is an AAV expressing Human BCL10.

AAV-202033

AAV-h-BCL10

Ready-to-use AAV expressing Human BCL10 (B-cell CLL/lymphoma 10). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

B-cell CLL/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; CARMEN; caspase-recruiting domain-containing protein; cCARMEN; c-E10; CED-3/ICH-1 prodomain homologous E10-like regulator; cellular homolog of vCARMEN; cellular-E10; CIPER; CLAP; hCLAP; IMD37; mammalian CARD-containing adapter molecule E10; mE10

Description (eCommerce)

B-cell lymphoma/leukemia 10 (Bcl10) promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. Bcl10 may be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Bcl10 Is a substrate for MALT1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O95999].

Description (Vector)

BCL10 was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Gene ID

8915

Gene Name (eCommerce)

B cell CLL/lymphoma 10

Gene Name (Vector)

B-cell CLL/lymphoma 10

Gene Symbol

BCL10

HGNC ID

HGNC:989

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

702

ORF Size (bp)

702 bp

Protein Name (eCommerce)

B-cell lymphoma/leukemia 10

RefSeq ID

NM_003921

RefSeq Synonyms

NM_003921, NM_001320715, BC053617,

Research Areas

Apoptosis,B-cell Receptor Signaling,Cancer,Fc Receptor Signaling,Immunology,Innate Immunity,Lysosome,Neurobiology,Neurodevelopment,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins

Research Areas (Faceted)

cancer,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.193516

UniProt ID (eCommerce)

O95999

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.