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human AUP1 Over-expression AAV

Name 
AAV-h-AUP1
Cat No 
AAV-201826
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human AUP1.

AAV-201826
AAV-h-AUP1

Ready-to-use AAV expressing Human AUP1 (ancient ubiquitous protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ancient ubiquitous protein 1
Description (eCommerce)
Ancient ubiquitous protein 1 (AUP1) may play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9Y679].
Description (Vector)
AUP1 encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. AUP1 overlaps the gene for mitochondrial serine protease 25.
Gene ID
550
Gene Name (eCommerce)
AUP1, lipid droplet regulating VLDL assembly factor
Gene Name (Vector)
ancient ubiquitous protein 1
Gene Symbol
AUP1
HGNC ID
HGNC:891
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1122
ORF Size (bp)
1122 bp
Protein Name (eCommerce)
Ancient ubiquitous protein 1
RefSeq ID
NM_181575
RefSeq Synonyms
NM_181575, BC033646, BC001658,
Research Areas
Ubiquitination
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
Ancient ubiquitous protein 1 (AUP1) may play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9Y679].
UniGene ID
Hs.411480
UniProt ID (eCommerce)
Q9Y679

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.