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human ATIC Over-expression AAV

Name 
AAV-h-ATIC
Cat No 
AAV-201651
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ATIC.

AAV-201651
AAV-h-ATIC

Ready-to-use AAV expressing Human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase; AICAR; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; AICAR transformylase; AICARFT; AICARFT/IMPCHASE; ATIC; bifunctional purine biosynthesis protein PURH; epididymis secretory sperm binding protein Li 70p; HEL-S-70p; IMP cyclohydrolase; IMP synthase; IMPCHASE; Inosinicase; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PURH
Description (eCommerce)
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) is bifunctional enzyme that catalyzes 2 steps in purine biosynthesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P31939].
Description (Vector)
ATIC encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.
Gene ID
471
Gene Name (eCommerce)
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene Name (Vector)
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene Symbol
ATIC
HGNC ID
HGNC:794
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1779
ORF Size (bp)
1779 bp
Protein Name (eCommerce)
Bifunctional purine biosynthesis protein PURH
RefSeq ID
NM_004044
RefSeq Synonyms
NM_004044, BC008879,
Research Areas
Cancer,Cytoskeleton,Epilepsy,Metabolism/Metabolic Process,Mitochondrion,Neurobiology
Research Areas (Faceted)
cancer,cell_biology,neurobiology,metabolism,cell_biology,neurobiology
Species
human
Target Sentence
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) is bifunctional enzyme that catalyzes 2 steps in purine biosynthesis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P31939].
UniGene ID
Hs.90280
UniProt ID (eCommerce)
P31939

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.