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human ASXL2 Over-expression AAV

Name 
AAV-h-ASXL2
Cat No 
AAV-201595
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ASXL2.

AAV-201595
AAV-h-ASXL2

Ready-to-use AAV expressing Human ASXL2 (additional sex combs like 2, transcriptional regulator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
additional sex combs like 2, transcriptional regulator; additional sex combs-like protein 2; ASXH2; polycomb group protein ASXH2; putative Polycomb group protein ASXL2; SHAPNS
Description (eCommerce)
The gene that encodes Additional sex combs-like protein 2 (ASXL2) is a homolog of the drosophila additional sex combs (Asx) gene. Drosophila Asx is in a class of proteins known as ETP (enhancers of trithorax and polycomb). ETP proteins regulate polycomb-group (PcG) and trithorax-group (trxG) proteins which function to modify the methylation of histones and structure of chromatin. Mutations in ASXL1 are implicated in the development of myelodysplastic syndromes (MDS), a group of hematological diseases characterized by ineffective hematopoiesis and a predisposition to acute myeloid leukemia (AML).
Description (Vector)
ASXL2 is a human homolog of the Drosophila asx gene. Drosophila asx is an enhancer of trithorax (see MIM 159555) and polycomb (see MIM 610231) (ETP) gene that encodes a chromatin protein with dual functions in transcriptional activation and silencing (Katoh and Katoh, 2003 (PubMed 12888926)).(supplied by OMIM, Sep 2009)
Gene ID
55252
Gene Name (eCommerce)
ASXL transcriptional regulator 2
Gene Name (Vector)
additional sex combs like 2, transcriptional regulator
Gene Symbol
ASXL2
HGNC ID
HGNC:23805
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2757
ORF Size (bp)
2757 bp
Protein Name (eCommerce)
Putative Polycomb group protein ASXL2
RefSeq ID
NM_018263
RefSeq Synonyms
NM_018263, BC042999,
Research Areas
Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
The gene that encodes Additional sex combs-like protein 2 (ASXL2) is a homolog of the drosophila additional sex combs (Asx) gene. Drosophila Asx is in a class of proteins known as ETP (enhancers of trithorax and polycomb). ETP proteins regulate polycomb-group (PcG) and trithorax-group (trxG) proteins which function to modify the methylation of histones and structure of chromatin. Mutations in ASXL1 are implicated in the development of myelodysplastic syndromes (MDS), a group of hematological diseases characterized by ineffective hematopoiesis and a predisposition to acute myeloid leukemia (AML).
UniGene ID
Hs.594386
UniProt ID (eCommerce)
Q76L83

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.