human ARID4B Over-expression AAV

Name
AAV-h-ARID4B

Cat No
AAV-201383

Availability
4-5 weeks

This is an AAV expressing Human ARID4B.

AAV-201383

AAV-h-ARID4B

Ready-to-use AAV expressing Human ARID4B (AT-rich interaction domain 4B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

180 kDa Sin3-associated polypeptide; ARID domain-containing protein 4B; AT rich interactive domain 4B (RBP1-like); AT-rich interactive domain-containing protein 4B; BCAA; BRCAA1; breast cancer-associated antigen 1; breast cancer-associated antigen BRCAA1; breast carcinoma-associated antigen; histone deacetylase complex subunit SAP180; Rb-binding protein homolog; RBBP1L1; RBP1L1; retinoblastoma-binding protein 1-like 1; SAP180; SIN3A-associated protein 180; sin3-associated polypeptide p180

Description (eCommerce)

ARID4B (AT-rich interactive domain-containing protein 4B) is also known as RbBP1L1 (retinoblastoma binding protein 1-like 1) and is a retinoblastoma binding protein and member of the AT-rich interaction domain (ARID) family of proteins. In addition to the ARID DNA binding domain, ARID4B also contains a chromo domain and a TUDOR domain, indicating a function in chromatin organization and protein-protein interactions with methylated protein substrates. As a subunit of the SIN3A transcriptional co-repressor, ARID4B is implicated to be involved in chromatin remodeling and epigenetic modifications. ARID4B may play a role in the pathogenesis of breast cancer and other malignancies.

Description (Vector)

ARID4B encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.

Gene ID

51742

Gene Name (eCommerce)

AT-rich interaction domain 4B

Gene Name (Vector)

AT-rich interaction domain 4B

Gene Symbol

ARID4B

HGNC ID

HGNC:15550

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3462

ORF Size (bp)

3462 bp

Protein Name (eCommerce)

AT-rich interactive domain-containing protein 4B

RefSeq ID

NM_016374

RefSeq Synonyms

NM_031371, NM_016374, NM_001206794, BC130418,

Research Areas

Chromatin Remodeling,Epigenetic Regulation of Gene Expression,Immunology,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,transcription_translation,immunology,genetics

Species

human

Target Sentence

UniGene ID

Hs.575782

UniProt ID (eCommerce)

Q4LE39

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.