human ARHGEF1 Over-expression AAV

Name 
AAV-h-ARHGEF1
Cat No 
AAV-201352
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ARHGEF1.

AAV-201352
AAV-h-ARHGEF1

Ready-to-use AAV expressing Human ARHGEF1 (Rho guanine nucleotide exchange factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
115 kDa guanine nucleotide exchange factor; 115-kD protein; GEF1; LBCL2; LSC; Lsc homolog; p115RhoGEF; P115-RHOGEF; Rho guanine nucleotide exchange factor (GEF) 1; rho guanine nucleotide exchange factor 1; SUB1.5
Description (eCommerce)
P115-RhoGEF plays a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. P115-RhoGEF acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. The gene name for p115-RhoGEF is ARHGEF1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92888].
Description (Vector)
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
Gene ID
9138
Gene Name (eCommerce)
Rho guanine nucleotide exchange factor 1
Gene Name (Vector)
Rho guanine nucleotide exchange factor 1
Gene Symbol
ARHGEF1
HGNC ID
HGNC:681
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2847
ORF Size (bp)
2847 bp
Protein Name (eCommerce)
Rho guanine nucleotide exchange factor 1
RefSeq ID
NM_004706
RefSeq Synonyms
NM_199002, NM_198977, NM_004706, BC067262, BC034013, BC011726,
Research Areas
Axonogenesis,Cancer,Cardiovascular,Cytoskeleton,EGFR Signaling,GPCR Signaling,Neurobiology,NGF Signaling,RAC1 Signaling,Rho Signaling,Signal Transduction
Research Areas (Faceted)
cardiovascular,cancer,signal_transduction,neurobiology,developmental_biology,cell_biology,signal_transduction,neurobiology
Species
human
Target Sentence
P115-RhoGEF plays a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. P115-RhoGEF acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. The gene name for p115-RhoGEF is ARHGEF1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92888].
UniGene ID
Hs.631550
UniProt ID (eCommerce)
Q92888

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.