human ARHGDIB Over-expression AAV

Name 
AAV-h-ARHGDIB
Cat No 
AAV-201348
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ARHGDIB.

AAV-201348
AAV-h-ARHGDIB

Ready-to-use AAV expressing Human ARHGDIB (Rho GDP dissociation inhibitor beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1; Rho GDI 2; Rho GDP dissociation inhibitor (GDI) beta; rho GDP-dissociation inhibitor 2; rho-GDI beta; RhoGDI2
Description (eCommerce)
ARHGDIB regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to the  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P52566].
Description (Vector)
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 (PubMed 8356058)).(supplied by OMIM, Dec 2010)
Gene ID
397
Gene Name (eCommerce)
Rho GDP dissociation inhibitor beta
Gene Name (Vector)
Rho GDP dissociation inhibitor beta
Gene Symbol
ARHGDIB
HGNC ID
HGNC:679
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
606
Protein Name (eCommerce)
Rho GDP-dissociation inhibitor 2
RefSeq ID
NM_001175
RefSeq Synonyms
NM_001321423, NM_001321422, NM_001321421, NM_001321420, NM_001175, BC009200,
Research Areas
Apoptosis,CD95/FAS Signaling,Cytoskeleton,Host-Virus Interactions,Immunology,Neurobiology,Rho Signaling,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
ARHGDIB regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to the  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P52566].
UniGene ID
Hs.504877
UniProt ID (eCommerce)
P52566

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.