human APOBEC3B Over-expression AAV

Name
AAV-h-APOBEC3B

Cat No
AAV-201182

Availability
4-5 weeks

This is an AAV expressing Human APOBEC3B.

AAV-201182

AAV-h-APOBEC3B

Ready-to-use AAV expressing Human APOBEC3B (apolipoprotein B mRNA editing enzyme catalytic subunit 3B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

A3B; APOBEC1L; ARCD3; ARP4; bK150C2.2; DJ742C19.2; PHRBNL

Description (Vector)

APOBEC3B is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

9582

Gene Name (Vector)

apolipoprotein B mRNA editing enzyme catalytic subunit 3B

Gene Symbol

APOBEC3B

HGNC ID

HGNC:17352

ORF Size (aa)

756

ORF Size (bp)

756 bp

RefSeq ID

NM_004900

RefSeq Synonyms

NM_004900, NM_001270411, BC053859,

Species

human

UniGene ID

Hs.226307

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.