human APOBEC3A Over-expression AAV

Name 
AAV-h-APOBEC3A
Cat No 
AAV-201180
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human APOBEC3A.

AAV-201180
AAV-h-APOBEC3A

Ready-to-use AAV expressing Human APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
A3A; ARP3; bK150C2.1; PHRBN
Description (Vector)
APOBEC3A is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
200315
Gene Name (Vector)
apolipoprotein B mRNA editing enzyme catalytic subunit 3A
Gene Symbol
APOBEC3A
HGNC ID
HGNC:17343
ORF Size (aa)
546
ORF Size (bp)
546 bp
RefSeq ID
NM_145699
RefSeq Synonyms
NM_145699, NM_001270406, BC144146, BC126416,
Species
human
UniGene ID
Hs.348983

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.