human APLP1 Over-expression AAV

Cat. No: AAV-201158

Availability: 3-5 weeks

Name: AAV-h-APLP1

This is an AAV expressing Human APLP1.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: APLP1
Gene Name: amyloid beta precursor like protein 1
Gene ID: 333
Gene Synonyms: APLP
ORF Size: 1953 bp
RefSeq#: BC012889
Gene Description: APLP1 encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
UniGene ID: Hs.74565
HGNC ID: HGNC:597