human ALDOA Over-expression AAV

Name
AAV-h-ALDOA

Cat No
AAV-200753

Availability
4-5 weeks

This is an AAV expressing Human ALDOA.

AAV-200753

AAV-h-ALDOA

Ready-to-use AAV expressing Human ALDOA (aldolase, fructose-bisphosphate A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ALDA; aldolase A, fructose-bisphosphate; epididymis secretory sperm binding protein Li 87p; fructose-1,6-bisphosphate triosephosphate-lyase; fructose-bisphosphate aldolase A; GSD12; HEL-S-87p; lung cancer antigen NY-LU-1; muscle-type aldolase

Description (eCommerce)

Aldolase A (fructose-bisphosphate aldolase) (ALDOA) is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia [taken from NCBI Entrez Gene (Gene ID: 226)].

Description (Vector)

ALDOA, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.

Gene ID

226

Gene Name (eCommerce)

aldolase, fructose-bisphosphate A

Gene Name (Vector)

aldolase, fructose-bisphosphate A

Gene Symbol

ALDOA

HGNC ID

HGNC:414

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1095

ORF Size (bp)

1095 bp

Protein Name (eCommerce)

Fructose-bisphosphate aldolase A

RefSeq ID

NM_000034

RefSeq Synonyms

NM_184043, NM_184041, NM_001243177, NM_001127617, NM_000034, BC016800, BC015888, BC013614, BC012880, BC010660, BC004333,

Research Areas

Breast Cancer,Cancer,Cytoskeleton,EGFR Signaling,HIF-1 Signaling,Metabolism/Metabolic Process,Signal Transduction

Research Areas (Faceted)

cancer,cell_biology,metabolism,signal_transduction

Species

human

Target Sentence

UniGene ID

Hs.513490

UniProt ID (eCommerce)

P04075

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.