human ADSL Over-expression AAV

Name 
AAV-h-ADSL
Cat No 
AAV-200514
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human ADSL.

AAV-200514
AAV-h-ADSL

Ready-to-use AAV expressing Human ADSL (adenylosuccinate lyase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
adenylosuccinase; adenylosuccinate lyase; ADSL; AMPS; ASASE; ASL
Description (eCommerce)
Adenylosuccinate Lyase / ADSL is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and, in some cases, growth retardation associated with muscle wasting and epilepsy [taken from NCBI Entrez Gene (Gene ID: 158)].
Description (Vector)
Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
158
Gene Name (eCommerce)
adenylosuccinate lyase
Gene Name (Vector)
adenylosuccinate lyase
Gene Symbol
ADSL
HGNC ID
HGNC:291
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1455
ORF Size (bp)
1455 bp
Protein Name (eCommerce)
Adenylosuccinate lyase
RefSeq ID
NM_000026
RefSeq Synonyms
NM_001317923, NM_001123378, NM_000026, BC000253,
Research Areas
Epilepsy,Hypoxia,Metabolism/Metabolic Process,Mitochondrion,Neurobiology
Research Areas (Faceted)
neurobiology,cell_biology,metabolism
Species
human
Target Sentence
Adenylosuccinate Lyase / ADSL is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and, in some cases, growth retardation associated with muscle wasting and epilepsy [taken from NCBI Entrez Gene (Gene ID: 158)].
UniGene ID
Hs.75527
UniProt ID (eCommerce)
P30566

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.